M. Lopez

Indicators to assess interannual variability in marine connectivity processes: a semi-theoretical approach

The paper defines and tests indicators to assess temporal variability in marine connectivity, showing their potential to improve conservation planning.

Control of the phage defence mechanisms by Quorum sensing (QS) in clinical isolates of Klebsiella pneumoniae

This study investigates how cinnamaldehyde inhibits quorum sensing in K. pneumoniae to reduce phage resistance by proteomic analysis and infection assays.

Female cichlids attack and avoid-but will still mate with-androgen receptor mutant males that lack male-typical body coloration

The paper investigates female cichlid mating behaviors by testing AR mutant males lacking coloration, finding aggression but mating occurs regardless of coloration.

Molecular Studies of Phages-Klebsiella pneumoniae in a Mucoid Environment: Innovative use of mucolytic agents prior to the administration of lytic phages

This study shows that mucin promotes phage resistance in K. pneumoniae, but mucolytic agents like NAC reduce this resistance, suggesting their potential use in phage therapy.

Epigenetic variation causes heritable variation in complex traits in the mollusk Biomphalaria glabrata, vector of the human parasite Schistosoma mansoni

The paper shows that epigenetic variation in Biomphalaria glabrata affects heritable complex traits like fecundity and resistance to Schistosoma mansoni.

Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis

This paper identifies leptin receptor-expressing sympathetic perineurial cells that produce IL33, which prevents BAT inflammation and obesity by supporting thermogenesis and immune regulation.

Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2

This study identifies T cell dysregulation, inflammation, and mis-coordinated adaptive immune responses in Long COVID patients compared to non-LC individuals.

Molecular analysis of the interactions between phages and the bacterial host Klebsiella pneumoniae

The paper analyzes molecular defense mechanisms in phages and Klebsiella pneumoniae through proteomic and genomic studies, revealing interactions such as CRISPR-Cas systems and toxin-antitoxin systems.

Liraglutide protects against diastolic dysfunction and improves ventricular protein translation

This study shows liraglutide reduces diastolic dysfunction in mice by enhancing cardiac protein translation and amino acid uptake, but also causes muscle mass loss.

Dynamic product-precursor relationships underlie cuticular lipid accumulation on maize silks

The study identifies how precursor chain length, plant genotype, and spatio-temporal gradients influence product-precursor ratios in the cuticular hydrocarbon-producing pathway of maize silks.

Implant- and anesthesia-related factors affecting threshold intensities for vagus nerve stimulation

This study identifies implant- and anesthesia-related factors influencing threshold intensities for vagus nerve stimulation, showing neural thresholds are lower than physiological thresholds and that anesthesia type and implant age significantly affect these thresholds.

Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome

This study identifies a skewed TCR repertoire in MIS-C patients, with TRBV11-2 expansion linked to disease severity and superantigen-like interactions with SARS-CoV-2 spike protein.

An automated, high throughput methodology optimized for quantitative cell-free mitochondrial and nuclear DNA isolation from plasma

The paper optimizes an automated high-throughput method for isolating cell-free mitochondrial and nuclear DNA from plasma, achieving 6-fold higher yields of mitochondrial DNA.

Pro-inflammatory response of non-inflammatory Classical monocytes stimulated with LPS in vitro.

The paper examines how non-inflammatory classical monocytes respond to LPS stimulation, finding they produce higher IL-1β and form a new subpopulation defined by CD14+CD16-CD163-.

EFA6B regulates a stop signal for collective invasion in breast cancer

This study shows that EFA6B loss promotes collective invasion in breast cancer by reprogramming cell-ECM interactions and activating CDC42, as seen in patient-derived invasive tumors.

Assessment of a loop-mediated isothermal amplification (LAMP) assay for the rapid detection of pathogenic bacteria from respiratory samples in patients with hospital-acquired pneumonia

This study evaluates a LAMP assay for rapid detection of common pathogens in respiratory samples from HAP patients, showing high specificity and sensitivity.

The demographic history and mutational load of African hunter-gatherers and farmers

This study analyzes the demographic history and mutational load of African hunter-gatherers and farmers using exome sequencing data, finding similar mutation loads despite differing demographic histories.