A kinetically-driven free exchange mechanism of EmrE antiport sacrifices coupling efficiency in favor of promiscuity
A. E. Robinson, N. E. Thomas, E. A. Morrison, B. Balthazor, K. A. Henzler-Wildman
This paper shows EmrE, a multidrug resistance transporter, uses a new kinetically-driven free exchange mechanism that allows promiscuous drug and proton transport, sacrificing coupling efficiency for speed and specificity.
bioRxiv · May 24, 2017Biophysics