Elaboration of a MALDI-TOF Mass Spectrometry-based Assay of Parkin Activity and High-Throughput screening platform for Parkin Activators
R. Traynor, J. Moran, M. U. Stevens, A. Knebel, B. Behrouz, K. Merchant, C. J. Hastie, P. Davies, M. Muqit, V. De Cesare
The paper develops two MALDI-TOF MS-based methods to quantify Parkin E3 ligase activity in vitro, enabling high-throughput screening of Parkin activators.
bioRxiv · Mar 4, 2022 · PreprintBiochemistry