Ongoing Replication Stress Response and New Clonal T Cell Development Discriminate Between Liver and Lung Recurrence Sites and Patient Outcomes in Pancreatic Ductal Adenocarcinoma
J. M. Link, C. Pelz, P. J. Worth, S. Owen, D. Keith, E. M. Langer, A. Grossblatt-Wait, A. L. Creason, J. Egger, H. Holly, I. English, K. MacPherson, M. Tsuda, J. Goecks, E. Demir, , R. C. Sears
This study identifies transcriptomic and immune features distinguishing liver and lung metastatic sites in PDAC, linking replication stress response and T cell clonal development to patient outcomes.
bioRxiv · May 4, 2022 · PreprintCancer Biology