R. C. Sears

This study shows that KRASG12D upregulates CIP2A, which inhibits PP2A-B56α, leading to c-MYC stabilization and promoting pancreatic cancer initiation.

The paper identifies prognostic spatial biomarkers in breast cancer by analyzing multiple clinical cohorts using three multiplex imaging technologies.

This paper develops a novel mouse model of TNBC by combining MYC amplification and PTEN deletion, showing it recapitulates human TNBC heterogeneity through omic analyses.

This study identifies transcriptomic and immune features distinguishing liver and lung metastatic sites in PDAC, linking replication stress response and T cell clonal development to patient outcomes.

Sulfopin, a selective Pin1 inhibitor, reduces tumor initiation and growth in neuroblastoma models by targeting c-Myc pathways.

This study identifies FGF1 from cancer-associated fibroblasts as a paracrine regulator of MYC in pancreatic cancer, showing its role in MYC stability and tumor formation.