Inhibition of CDK4/6 Overcomes Primary Resistance to PD-1 Blockade in Malignant Mesothelioma
H.-J. Jang, C. Y. Truong, E. M. Lo, H. M. Holmes, D. Ramos, M. Ramineni, J.-S. Lee, D. Y. Wang, M. Pietropaolo, R. T. Ripley, B. Burt, H.-S. Lee
This study identifies CDK4/6 as a therapeutic target to overcome primary resistance to PD-1 blockade in malignant mesothelioma by analyzing genomic and immunogenomic data.
bioRxiv · Mar 4, 2021Immunology