Cooperative Gsx2-DNA Binding Requires DNA Bending and a Novel Gsx2 Homeodomain Interface
J. Webb, E. Farrow, B. Cain, Z. Yuan, A. Yarawsky, E. Schoch, E. K. Gagliani, A. B. Herr, B. Gebelein, R. A. Kovall
This study investigates how Gsx2 binds DNA cooperatively, revealing structural and thermodynamic mechanisms underlying its dimeric DNA binding and specificity.
bioRxiv · Dec 8, 2023Biochemistry