Z. Yuan

This study shows mechanical force is critical for PD-1 function, as soluble PD-L1 lacks the mechanical support needed to trigger PD-1 signaling.

This study identifies key residues in the BAK:VDAC2 interaction, showing that disrupting this interaction can inhibit or promote apoptosis depending on the context.

This study shows METTL3 reduces blood pressure by stabilizing RUNX1b mRNA via m6A modification, increasing eNOS expression in endothelial cells.

This study investigates how Gsx2 binds DNA cooperatively, revealing structural and thermodynamic mechanisms underlying its dimeric DNA binding and specificity.

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

This study identifies a minimal bacterial consortium that efficiently drives nitritation at acidic pH through metabolic interactions and stress adaptation mechanisms.

This study identifies circNP37, a circRNA derived from H1N1 influenza virus, which enhances viral replication by sequestering host miR-361-5p.

This study demonstrates nitrate-dependent anaerobic oxidation of ethane and butane by Candidatus Alkanivorans nitratireducens, revealing the fumarate addition pathway's role in SCGA metabolism.

This study identifies the molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation by analyzing cleavage specificity across species.

This paper develops FUS-CRISPR(a/i) tools to remotely control gene expression and epigenetic modifications in vivo, showing therapeutic effects in tumor models.

This study uses cryo-EM to analyze the structural dynamics of yeast Pol α-primase during primer synthesis, revealing how RNA primers are transferred to DNA polymerase and how primer length is regulated.

This paper develops engineered retrovirus-like nanocarriers for efficient mRNA delivery into neurons by modifying extracellular vesicles with Arc protein capsids and RNA elements.

The paper profiles global mosquito viromes across species, locations, and climates, identifies core-viruses, and links viral diversity to ecological factors and mosquito movement.

This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.

This study shows that Gal-9 treatment during ART increases HIV DNA and RNA in tissues of humanized mice, suggesting it promotes HIV persistence.

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.

This study examines how sugarcane rhizosphere fungal communities change over time, identifying key fungal genera and environmental drivers affecting their structure and disease risk.

The paper quantifies cooperative cis-interactions between TCRβ and CD3 subunits, showing they form catch bonds that mechanically regulate TCR signaling.

The paper develops a pipeline to analyze grain quality traits in hybrid rice by identifying additive and dominant genetic loci, improving prediction accuracy for hybrid performance.

This paper defines the RBPJ-interacting domain of L3MBTL3 and reports the crystal structure of the RBPJ-L3MBTL3-DNA complex, revealing molecular interactions and functional consequences of mutations.

This study examines how Salmonella develops resistance to enrofloxacin under varying sub-inhibitory concentrations, identifying gene expression changes and mutations involved in resistance.

The paper investigates how genetic variants in the ACE2 gene affect susceptibility to SARS-CoV-2 infection by analyzing their impact on viral entry.

This study analyzes mosquito species and viromes in Wuhan, China, from April to October 2020, revealing seasonal changes and stable viruses in Culex mosquitoes.

This study establishes three clinical breakpoint values for danofloxacin against Glaesserella parasuis using epidemiological, pharmacodynamic, and clinical data.

This study shows that delivering a childhood vaccine antigen via attenuated Listeria improves immunotherapy for pancreatic cancer by converting cold tumors into hot tumors and enhancing T cell activity.

The paper identifies differential antiviral effects of IFN-alpha subtypes against SARS-CoV-2 and highlights IFN5's superior activity, suggesting therapeutic potential.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study identifies RNF5 as an E3 ligase that ubiquitinates SARS-CoV-2 M protein at K15, stabilizing the M-E complex and inducing autophagy for viral release.