The mechanosensitive TRPV2 calcium channel controls melanoma invasiveness and metastatic potential.
K. F. Shoji, E. Bayet, D. Le Devedec, A. Mallavialle, S. Marionneau-lambot, S. Leverrier-Penna, F. Rambow, R. Perret, A. Joussaume, R. Viel, A. Fautrel, A. Khammari, B. Constantin, S. Tartare-Deckert, A. Penna
This study identifies TRPV2 calcium channel as a driver of melanoma invasiveness and metastasis, showing its role in regulating cell motility and providing a therapeutic target.
bioRxiv · Oct 22, 2021Cancer Biology