F. Rambow

ALDH1A3-acetaldehyde metabolism potentiates transcriptionalheterogeneity in melanoma

This study shows ALDH1A3 and ACSS2 coordinate acetaldehyde-acetyl-CoA metabolism with histone acetylation in melanoma, contributing to transcriptional heterogeneity and drug resistance.

A TCF4/BRD4-dependent regulatory network confers cross-resistance to targeted and immune checkpoint therapy in melanoma

This study identifies a TCF4/BRD4-dependent regulatory network that drives cross-resistance to ICB and targeted therapy in melanoma by analyzing scRNA-seq data from a longitudinal cohort.

Anticancer immunotherapies transition postcapillary venules into high-endothelial venules that generate TCF1+ T lymphocyte niches through a feed-forward loop

This paper shows that antiangiogenic immunotherapies convert postcapillary venules into high-endothelial venules that support TCF1+ T cell niches through a feed-forward loop involving CD8 and NK cells.

The mechanosensitive TRPV2 calcium channel controls melanoma invasiveness and metastatic potential.

This study identifies TRPV2 calcium channel as a driver of melanoma invasiveness and metastasis, showing its role in regulating cell motility and providing a therapeutic target.

Emerging single cell endothelial heterogeneity supports sprouting tumour angiogenesis and growth

The paper identifies a novel endothelial cell population in tumors that contributes to vascularization and growth.

Dynlt3, a novel fundamental regulator of melanosome movement, distribution, maturation and transfer

This study identifies Dynlt3 as a critical regulator of melanosome transport, maturation, and transfer in melanocytes, revealing its role in skin pigmentation through interactions with the Wnt/β-catenin pathway.

BRN2 is a non-canonical melanoma tumor-suppressor

This study identifies BRN2 as a non-canonical tumor suppressor in melanoma, showing its role in initiation and progression through PTEN regulation and PI3K signaling.

A neural crest stem cell-like state drives nongenetic resistance to targeted therapy in melanoma

This study identifies a neural crest stem cell-like state in melanoma minimal residual disease that drives nongenetic resistance to MAPK-targeted therapy and shows that targeting FAK/SRC signaling can delay relapse.

Mitochondrial determinants of response and resistance to venetoclax plus cytarabine duplet therapy in acute myeloid leukemia

This study identifies mitochondrial determinants of response and resistance to venetoclax plus cytarabine therapy in AML, showing that OxPHOS is a predictive marker and that targeting ETCI improves outcomes.