Model-based intensification of CHO cell cultures: one-step strategy from fed-batch to perfusion
A. Richelle, B. Corbett, P. Agarwal, A. Vernersson, J. Trygg, C. McCready
The paper presents a model-based strategy to optimize perfusion cultures of CHO cells using data from fed-batch experiments, achieving successful prediction across different operating modes with a single parameter set.
bioRxiv · May 19, 2022 · PreprintBioengineering