P. Agarwal

PLAbDab-nano: a database of camelid and shark nanobodies from patents and literature

PLAbDab-nano is a database of 5000 annotated VHH and VNAR nanobody sequences from camelids and sharks, providing a resource for designing libraries and finding similar sequences.

A novel repressor-activator-competitor module comprising C2H2 zinc finger and NAC transcription factors regulates rice grain development

This study identifies a repressor-activator-competitor module involving ZOS1-15 and ONAC024 that regulates rice grain development through interactions with other transcription factors and co-repressors.

A zinc finger transcriptional repressor ZOS5-09 regulates rice grain size, starch and protein biosynthesis

This study identifies ZOS5-09 as a transcriptional repressor that regulates rice grain size, starch, and protein biosynthesis by modulating cell proliferation, expansion, and gene expression.

The Observed T cell receptor Space database enables paired-chain repertoire mining, coherence analysis and language modelling

The paper introduces the OTS database, a curated resource of paired-chain TCR sequences, and develops a language model for analyzing TCR pairings and coherence.

Evidence of 14-3-3 proteins contributing to kinetochore integrity and chromosome congression during mitosis

This study shows that 14-3-3 proteins in yeast are essential for kinetochore integrity and proper chromosome segregation during mitosis.

A non-canonical Arp2/3 complex is essential for Plasmodium DNA segregation and transmission of malaria.

This study identifies a non-canonical Arp2/3 complex in Plasmodium essential for DNA segregation during male gametogenesis and transmission to mosquitoes.

Non-essential kinetochore proteins contribute to meiotic chromosome condensation through polo-like kinase

The paper investigates the role of non-essential kinetochore proteins in meiotic chromosome condensation and finds that Ctf19 influences condensation by modulating Cdc5 activity and condensin stability.

Confined environment facilitates stacked conformations in Holliday Junction

This study investigates how confinement affects Holliday Junction conformation using reverse micelles, finding that stacked conformations are preferred even at low divalent cation concentrations.

Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

This study analyzes NSP10 variants in SARS-CoV-2 using genomic data and biophysical methods, finding limited functional changes and strong conservation in its interactions with NSP14 and NSP16.

Intrinsic disorder in CENP-ACse4 tail and its chaperone facilitates synergistic association for kinetochore stabilization

This study investigates the interaction between the disordered Cse4 N-tail and its chaperone Scm3, showing how their synergistic association facilitates kinetochore stabilization through electrostatic interactions and reduced disorder.

Model-based intensification of CHO cell cultures: one-step strategy from fed-batch to perfusion

The paper presents a model-based strategy to optimize perfusion cultures of CHO cells using data from fed-batch experiments, achieving successful prediction across different operating modes with a single parameter set.

Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1

This study investigates how Rev1 discriminates between nucleotides during translesion synthesis, showing structural differences in hydrogen bonding and sugar pucker when using dCTP versus rCTP.

Actin capping protein regulates actomyosin contractility to maintain germline architecture in C. elegans

This study shows that CAP-1 regulates actomyosin contractility in C. elegans germline, maintaining structure and fertility by controlling F-actin and myosin II levels.

Integrated Systems-Analysis of the Human and Murine Pancreatic Cancer Glycomes Reveal a Tumor Promoting Role for ST6GAL1

The paper identifies ST6GAL1 as a promoter of pancreatic cancer using integrated glycomic and transcriptomic analysis across human and mouse models, showing delayed cancer formation and reduced fibrosis in a novel ST6GAL1 knockout model.

The Cardiolipin Transacylase Tafazzin Regulates Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets from Mice

This study shows that Tafazzin deficiency in pancreatic islets reduces insulin secretion and mitochondrial function under low-glucose conditions.

Developing synergistic drug combinations to restore antibiotic sensitivity in drug-resistant Mycobacterium tuberculosis

Visualizing Rev1 Catalyze Protein-template DNA Synthesis

This study uses time-lapse X-ray crystallography to visualize Rev1's mechanism of catalyzing protein-template DNA synthesis, revealing key steps in nucleotide incorporation and product release.

Effect of topical soluble epoxide hydrolase inhibition in a preclinical diabetic wound healing model.

This study tests a topical EPHX2 inhibitor, GSK2256294, in a diabetic wound model, showing improved healing compared to vehicle but not meeting statistical significance.