NOD1 is super-activated through spatially-selective ubiquitination by the Salmonella effector SspH2
C. Delyea, S. Y. Luo, B. E. Dubrule, O. Julien, A. P. Bhavsar
This paper identifies SspH2 as an E3 ubiquitin ligase that super-activates NOD1 and NOD2 through spatially-selective ubiquitination, enhancing pro-inflammatory cytokine secretion via the NF-κB pathway.
bioRxiv · Oct 8, 2021 · PreprintMicrobiology