MicrobiologybioRxivPreprint
NOD1 is super-activated through spatially-selective ubiquitination by the Salmonella effector SspH2
C. Delyea, S. Y. Luo, B. E. Dubrule…·A. P. Bhavsar
This paper identifies SspH2 as an E3 ubiquitin ligase that super-activates NOD1 and NOD2 through spatially-selective ubiquitination, enhancing pro-inflammatory cytokine secretion via the NF-κB pathway.
DOI 10.1101/2021.10.08.463692