Simultaneous in vitro simulation of multiple antimicrobial agents with different elimination half-lives in a pre-clinical infection model
I. Kesisoglou, B. Eales, K. R. Ledesma, P. R. Merlau, V. H. Tam, W. Wang, M. Nikolaou
The paper develops a method to simulate the pharmacokinetics of multiple antimicrobial agents in vitro, validated with three antibiotics having different elimination half-lives.
bioRxiv · Dec 21, 2020Pharmacology & Toxicology