W. Wang

Neurocognitive deficits in controlling aversive memory among insomnia disorders

This study investigates memory control impairments in insomnia disorder, finding reduced suppression-induced forgetting and altered electrophysiological responses during memory suppression tasks.

A ubiquitous Streptomyces biosynthetic megacluster encodes an arsenal of synergistic biotin-targeting antibiotics

The paper identifies a conserved Streptomyces biosynthetic megacluster producing biotin-targeting antibiotics, effective against multidrug-resistant E. coli.

An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

The paper develops a co-culture model of lung cancer organoids and peripheral blood mononuclear cells to study systemic anti-tumor immunity and predict immunotherapy outcomes.

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

This study identifies FRMD8 as a regulator of ER levels in ER-positive breast cancer, showing it confers tamoxifen resistance through dual mechanisms involving transcriptional and post-translational regulation of ER.

Projections between the globus pallidus externa and cortex span motor and non-motor regions

The paper identifies two distinct electrophysiological and molecular phenotypes of pallidocortical neurons projecting to motor and non-motor cortical regions, revealing a closed-loop circuit between the GPe and cortex.

Bioadhesive Hydrogel-Coupled and Miniaturized Ultrasound Transducer System for Long-Term, Wearable Neuromodulation

This paper develops a wearable ultrasound device with bioadhesive hydrogel for long-term neuromodulation, demonstrating its effectiveness in suppressing somatosensory responses over 28 days.

Targeting IRE1alpha improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice

This study shows that inhibiting IRE1 improves insulin sensitivity, thermogenesis, and reduces metabolically active adipose tissue macrophages in obese mice.

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

Molecular Insights into AGS3's Role in Spindle Orientation: A Biochemical Perspective

This study investigates AGS3's role in spindle orientation, showing it differs from LGN due to structural differences and regulatory interactions with Insc.

The metabolic benefits of thermogenic stimulation are preserved in aging

This study shows that chronic beta3-AR stimulation improves metabolic function in aged mice by enhancing thermogenesis in brown adipose tissue and lipid turnover in white adipose tissue.

Confinement, jamming, and adhesion in cancer cells dissociating from a collectively invading strand

This study investigates how cancer cells dissociate from an invading front, finding that single-cell rupture is most common and influenced by adhesion and chemotaxis.

scCancerExplorer: a comprehensive database for interactively exploring single-cell multi-omics data of human pan-cancer

scCancerExplorer provides an interactive database for exploring single-cell multi-omics data across 50 cancer types, integrating genomic, epigenomic, and transcriptomic data.

Digital Immunoassay for Rapid Detection of SARS-CoV-2 Infection in a Broad Spectrum of Animals

This paper develops a digital immunoassay for rapid detection of SARS-CoV-2 antibodies in multiple animal species with high sensitivity and specificity.

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

Increased pathogenicity and transmission of SARS-CoV-2 Omicron XBB.1.9 sublineage, including HK.3 and EG.5.1

This study investigates the virological features of SARS-CoV-2 Omicron XBB.1.9 subvariants, finding increased pathogenicity and transmissibility in HK.3 and EG.5.1 compared to previous variants.

Biochemical characterization of extended-spectrum β-lactamases from Akkermansia genus

The paper characterizes β-lactamases from Akkermansia species, showing they exhibit extended-spectrum activity and lack transferable resistance genes.

Monocytes Mobilized by Gut Neurons Remodel the Enteric Nervous System

The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

Structures of PSI-FCPI from Thalassiosira pseudonana in high light provide convergent evolution and light-adaptive strategies in diatom FCPIs

The paper reports cryo-EM structures of PSI-FCPI complexes from Thalassiosira pseudonana under high light, revealing light-adaptive strategies and convergent evolution in diatom FCPIs.

Brain implantation of tissue-level-soft bioelectronics 1 via embryonic development

This paper introduces a stretchable microelectrode array that integrates into the developing brain, enabling long-term, stable neural activity tracking without disrupting development.

RESPIRATION DEFECTS LIMIT SERINE SYNTHESIS REQUIRED FOR LUNG CANCER GROWTH AND SURVIVAL

This study shows that mitochondrial DNA mutations in NSCLC cause respiration defects, leading to glucose dependency, reduced serine synthesis, and increased cancer survival.

Collective phases and long-term dynamics in a fish school model with burst-and-coast swimming

This paper introduces a fish school model with burst-and-coast swimming that replicates collective phases like schooling and swarming, but cohesion diminishes over time except in swarming.

SASH1 impairs melanin synthesis and metastasis by down-regulating the TGF-β signaling pathway

This study shows SASH1 reduces melanin synthesis and metastasis by suppressing TGF-β1 signaling through regulation of THBS1 in melanocytes.

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.

Validating the Target Functions and Synergistic Multi-Target, Multi-Pathway Action Mode of Compound Kushen Injection Using CRISPR/CAS

This study validates the multi-target, multi-pathway action of Compound Kushen Injection by knocking out key genes in cell lines and observing changes in CKI efficacy.

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

This paper develops a nanocluster-antibody-drug conjugate (NADC) for interstitial cystitis, showing it targets NGF-overexpressing bladder lesions and reduces inflammation in rat models.

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

This study analyzes the humoral immune response to SARS-CoV-2 XBB and JN.1 lineages, showing JN.1 elicits superior neutralization and highlights the need for JN.1-based vaccine boosters.

Proteolytic processing of both RXLR and EER motifs in oomycete effectors

The paper shows that RXLR and EER motifs in oomycete effectors are proteolytically processed before secretion, with cleavage sites constrained to specific positions.

A New Large-Scale Extracellular Vesicle Production Strategy for Biomedical Drug Development

This paper introduces a novel large-scale EV production strategy with upstream fed-batch suspension cell culture and downstream chromatographic purification for clinical applications.