Mechanism of selectivity reveals novel antifolate drug interactions
S. L. Kordus, E. A. Lamont, M. D. Howe, A. A. Bauman, W. McCue, B. Finzel, A. D. Baughn
This study investigates PAS selectivity and finds it can antagonize sulfonamides and cause GI toxicity, suggesting caution in co-treatment for HIV-AIDS/M. tuberculosis co-infected individuals.
bioRxiv · Sep 18, 2020 · PreprintMicrobiology