Author

M. D. Howe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. D. Baughn· 4 shared A. A. Bauman· 2 shared S. L. Kordus· 2 shared Y. Minato· 2 shared A. Berger· 1 shared A.-L. Kiffe-Delf· 1 shared B. Burckhardt· 1 shared B. Finzel· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersMicrobiology

A. D. Baughn

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Author profile →

4 papers

Recent·Most cited

α-Aminooxyacetic acid derivatives acting as pro-drugs against Mycobacterium tuberculosis

K. Vill, L. van Geelen, O. Michel, A.-L. Kiffe-Delf, A. Berger, D. Podlesainski, K. Stenzel, F. Kovacic, B. Lungerich, B. Burckhardt, T. A. :Crooks, M. D. Howe, L. Ostrer, Z. Jia, T. R. Ioerger, , R. Kalscheuer

This study identifies novel anti-TB pro-drugs based on α-aminooxyacetic acid that are effective against M. tuberculosis and show low cytotoxicity.

bioRxiv · Apr 4, 2024 · PreprintMicrobiology

Pyrazinamide action is driven by the cell envelope stress response in Mycobacterium tuberculosis

J. M. Thiede, N. Dillon, M. D. Howe, S. J. Modlin, R. Aflakpui, S. Hoffner, F. Valafar, Y. Minato, A. D. Baughn

This study identifies that the cell envelope stress response drives pyrazinamide susceptibility in Mycobacterium tuberculosis, independent of pH, and shows that peptidoglycan synthesis inhibitors enhance its action.

bioRxiv · Feb 17, 2021 · PreprintMicrobiology

Mechanism of selectivity reveals novel antifolate drug interactions

S. L. Kordus, E. A. Lamont, M. D. Howe, A. A. Bauman, W. McCue, B. Finzel, A. D. Baughn

This study investigates PAS selectivity and finds it can antagonize sulfonamides and cause GI toxicity, suggesting caution in co-treatment for HIV-AIDS/M. tuberculosis co-infected individuals.

bioRxiv · Sep 18, 2020 · PreprintMicrobiology

Methionine antagonizes para-aminosalicylic acid activity via affecting folate precursor biosynthesis pathway in Mycobacterium tuberculosis

M. D. Howe, S. L. Kordus, M. S. Cole, A. A. Bauman, C. C. Aldrich, A. D. Baughn, Y. Minato

This study identifies methionine's role in antagonizing PAS activity by affecting folate precursor biosynthesis in M. tuberculosis.

bioRxiv · May 17, 2018Microbiology