Functional immune mapping with deep-learning enabled phenomics applied to immunomodulatory and COVID-19 drug discovery
M. F. Cuccarese, B. A. Earnshaw, K. Heiser, B. Fogelson, C. T. Davis, P. F. McLean, H. B. Gordon, K.-R. Skelly, F. L. Weathersby, V. Rodic, I. K. Quigley, E. D. Pastuzyn, B. M. Mendivil, N. H. Lazar, C. A. Brooks, , C. C. Gibson
This paper develops a deep-learning enabled phenomics platform to identify immune-modulating compounds and applies it to study SARS-CoV-2 infection and cytokine storm, identifying clinically relevant compounds and new drug candidates.
bioRxiv · Aug 2, 2020 · PreprintImmunology