Cancer BiologybioRxivPreprint
Loss of tristetraprolin activates NF-κB induced phenotypic plasticity and primes transition to lethal prostate cancer
K. L. Morel, A. A. Hamid, B. G. Falcon…·L. Ellis
This study shows that loss of ZFP36 promotes NF-κB activation and phenotypic plasticity in prostate cancer, leading to aggressive disease and castration resistance, which can be reversed by NF-κB inhibition.
DOI 10.1101/2022.08.05.500896