The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes
P. C. de Greef, T. Oakes, B. Gerritsen, M. Ismail, J. M. Heather, R. Hermsen, B. Chain, R. J. de Boer
The paper estimates the distribution of clone sizes in the human naive T-cell receptor repertoire and finds that while most clones are small, some large clones exist due to peripheral selection.
bioRxiv · Jul 3, 2019Immunology