Towards a robust comparison of diversity between sampled TCR repertoires
The paper examines how TCR repertoire diversity changes with age and highlights challenges in interpreting these changes due to confounding factors and limited sample sizes.
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3 papers
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The paper examines how TCR repertoire diversity changes with age and highlights challenges in interpreting these changes due to confounding factors and limited sample sizes.
P. C. de Greef, T. Oakes, B. Gerritsen…·R. J. de Boer
The paper estimates the distribution of clone sizes in the human naive T-cell receptor repertoire and finds that while most clones are small, some large clones exist due to peripheral selection.