Cancer BiologybioRxiv
Resistance to decitabine and 5-azacytidine emerges from adaptive responses of the pyrimidine metabolism network
X. Gu, R. Tohme, B. Tomlinson…·Y. Saunthararajah
This paper identifies adaptive metabolic responses in pyrimidine metabolism as a mechanism of resistance to decitabine and 5-azacytidine, and shows that alternating these drugs with metabolic inhibitors can extend DNMT1 depletion and delay leukemia relapse.
DOI 10.1038/s41375-020-1003-x