X. Gu

Wolbachia strain wMelM disrupts egg retention by Aedes aegypti females prevented from ovipositing

This study evaluates the impact of Wolbachia strains wAlbB and wMelM on egg retention and viability in Aedes aegypti females under extended egg retention conditions, finding greater negative effects with wMelM.

RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer

This study shows RGS10 deficiency promotes breast cancer metastasis via EMT by mechanisms involving lipocalin-2 and miR-539-5p.

Blockade of TREM2 ameliorates pulmonary inflammation and fibrosis by modulating sphingolipid metabolism

This study shows that blocking TREM2 reduces pulmonary inflammation and fibrosis by altering sphingolipid metabolism and chemokine expression in macrophages.

Hormetic effect induced by Beauveria bassiana in Myzus persicae

This paper shows that low concentrations of the fungal biopesticide Beauveria bassiana enhance aphid longevity and fecundity, with effects persisting across generations, while high concentrations cause mortality.

The expression of PKM1 and PKM2 in developing, benign, and cancerous prostatic tissues

This study examines PKM1 and PKM2 expression in mouse and human prostatic tissues across development, benign, and cancerous states, revealing distinct patterns in PCa and NEPCa.

Integrated Cell Landscape and Dynamics in the Progression of Bone Repair

The paper maps cell landscape and dynamics in rodent bone repair using single-cell RNA sequencing and identifies functional roles of myeloid and lymphoid cells in osteogenesis and angiogenesis.

Mass spectrometry of RNA-binding proteins during liquid-liquid phase separation reveals distinct assembly mechanisms and droplet architectures

The paper uses mass spectrometry and simulations to study phase separation of RNA-binding proteins, revealing distinct assembly mechanisms and droplet structures.

Developing Wolbachia-based disease interventions for an extreme environment

This study evaluates Wolbachia strains in Saudi Arabian mosquitoes for dengue suppression in extreme environments, finding reduced heat tolerance and local adaptation effects.

Porous microneedle patch with sustained exosome delivery repairs severe spinal cord injury

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

Dynamics of Borrelia Burgdorferi Invasion and Intravasation in a Tissue Engineered Dermal Microvessel Model

This study uses a tissue-engineered human dermal microvessel model to investigate Borrelia burgdorferi invasion and intravasation, finding no adhesin-mediated interactions and showing Bb-induced endothelium activation.

Injectable hydrogel embedded with mesenchymal stem cells repairs severe spinal cord injury

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

Protective human anti-poxvirus monoclonal antibodies are generated from rare memory B cells isolated by multicolor antigen tetramers

The paper isolates rare memory B cells from vaccinated individuals to generate anti-poxvirus monoclonal antibodies, identifying one with high efficacy against viral infection.

Site-specific validation and quantification of RNA 2'-O-methylation by qPCR with RNase H

This study develops Nm-VAQ, a qPCR-based method to precisely validate and quantify RNA 2'-O-methylation sites, demonstrating its application on rRNA.

Using NAMs to characterize chemical bioactivity at the transcriptomic, proteomic and phosphoproteomic levels

This paper integrates multi-omic data to characterize chemical bioactivity at transcriptomic, proteomic, and phosphoproteomic levels, showing how early phosphoproteomic changes drive downstream effects.

Small Molecules Restore Azole Activity Against Drug-Tolerant and Drug-Resistant Candida Isolates

This paper identifies small molecules that restore azole antifungal activity against drug-resistant and drug-tolerant Candida isolates, enhancing fluconazole efficacy and improving host survival in an infection model.

Integrated platform for multi-scale molecular imaging and phenotyping of the human brain

The paper develops a platform for multi-scale molecular imaging and phenotyping of the human brain, integrating novel tools for tissue processing, imaging, and computational reconstruction.

A wMel Wolbachia variant in Aedes aegypti from field-collected Drosophila melanogaster with increased phenotypic stability under heat stress

This study transfers a wMel Wolbachia variant from Drosophila melanogaster to Aedes aegypti, showing improved heat tolerance and cytoplasmic incompatibility under stress.

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

This paper identifies two conserved regions on the Omicron RBD recognized by broadly neutralizing antibodies and develops an inhalable bispecific antibody with broad neutralization and therapeutic efficacy in mice.

A decade of stability for wMel Wolbachia in natural Aedes aegypti populations

This study shows that the wMel Wolbachia strain remains stable in Aedes aegypti populations over a decade, with no significant phenotypic or genomic changes affecting its disease-blocking capabilities.

Vectorial Channeling as a Mechanism for Translational Control by Functional Prions and Condensates

The paper shows how mRNA/prion assemblies regulate translation through vectorial channeling, with repression or activation depending on mRNA distribution and assembly structure.

Comparative genomic and pan-genomic characteristion of Staphylococcus epidermidis from different sources unveils the molecular basis and potential biomarkers of pathogenic strains

This study sequenced and analyzed 11 ocular trauma-sourced S. epidermidis genomes, identifying 10 potential biomarkers and revealing pathogenic strains may be independent of biofilm formation.

A wAlbB Wolbachia transinfection displays stable phenotypic effects across divergent Aedes aegypti mosquito backgrounds

This study shows that a Wolbachia transinfection (wAlbBQ) remains stable in different Aedes aegypti backgrounds and exhibits consistent phenotypic effects.

The first report and biological characteristics of Helcococcus ovis isolated from clinical bovine mastitis in a Chinese dairy herd

This study isolates and characterizes Helcococcus ovis from clinical bovine mastitis in China, showing its antimicrobial sensitivity and pathogenic potential in a murine model.

Bacterial diversity of chronic middle ear lesions revealed by high-throughput sequencing

This study compares bacterial diversity in chronic middle ear lesions using 16S rRNA gene sequencing, finding greater diversity in cholesteatoma than in chronic suppurative otitis media lesions.

Association of CD44-/CD24- Breast Cancer Cells with Late Stage Tumor Recurrence

This study links CD44-/CD24- breast cancer cells to late-stage tumor recurrence and identifies RHBDL2 as a regulator of CSC conversion.

Immunogenicity of novel mRNA COVID-19 vaccine MRT5500 in mice and non-human primates

This study evaluates the immunogenicity of the mRNA vaccine MRT5500 in mice and non-human primates, showing it elicits neutralizing antibodies and TH1-biased responses.

Plasma Membrane Phylloquinone Biosynthesis in Nonphotosynthetic Parasitic Plants

The paper identifies plasma membrane phylloquinone biosynthesis in nonphotosynthetic parasitic plants and suggests its role in transmembrane redox signaling.

The Arabidopsis R-SNARE VAMP714 is essential for polarization of PIN proteins in the establishment and maintenance of auxin gradients.

This study shows that the Arabidopsis R-SNARE VAMP714 is essential for PIN protein polarization, auxin transport, and root development.

Evolutionary Transcriptome Analysis Based on Differentially Expressed (DE) Genes

This paper develops a new method to estimate transcriptome distance between species using p-value profiles from differentially expressed genes, showing satisfactory statistical performance in simulations.

A Statistical Framework for Evolutionary Analysis of Recurrent Somatic Mutations in Cancers

The paper develops a statistical framework to identify cancer-driving mutations by analyzing somatic mutations in 294 cancer genes from TCGA data.