C. Hong

Intracellular Ebola Virus nucleocapsid assembly revealed by in situ cryo-electron tomography.

This study uses cryo-electron tomography to reveal the structure of the intracellular Ebola virus nucleocapsid, identifying a new outer layer of NP complexed with VP35 and conserved assembly interfaces.

Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma

The paper identifies tumor-specific alternative splicing events in glioma that could generate cell-surface antigens but finds significant spatiotemporal heterogeneity and lack of proteomic evidence.

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

The paper identifies tumor-wide splicing aberrations that generate public neoantigens, enabling T-cell-based immunotherapies targeting intratumoral heterogeneity.

KARS mediates intra-translational deposition of N6-acetyl-L-lysine in nascent proteins to contribute the acetylome in cells

The paper identifies KARS as mediating intra-translational deposition of N6-acetyl-L-lysine in nascent proteins, contributing to the acetylome in mice.

Factors Affecting Protein Recovery During Hsp40 Affinity Profiling

This study evaluates methods to improve Hsp40 affinity profiling for identifying stress-induced misfolded proteins, finding DNAJB8H31Q remains the most effective recognition element under stress.

BET inhibition sensitizes immunologically-cold Rb-deficient prostate cancer to immune checkpoint blockade

This paper shows that BET inhibition makes immunologically cold Rb-deficient prostate cancer more responsive to immune checkpoint blockade by reprogramming the tumor microenvironment through STING/NF-κB/IFN signaling.

Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo

The paper identifies Stat1 inactivation as a mechanism by which aneuploid cancers evade immune surveillance in mice and humans.

Sequential single cell transcriptional and protein marker profiling reveals TIGIT as a marker of CD19 CAR-T cell dysfunction in patients with non-Hodgkin lymphoma

The paper identifies TIGIT as a marker of CD19 CAR-T cell dysfunction in NHL patients through single-cell transcriptional and protein profiling.

Single-Cell Analysis of Hyperthermic Intraperitoneal Chemotherapy Treated Tumors Reveals Distinct Cellular and Molecular Responses

This study uses single-cell RNA-seq to analyze tumor responses to HIPEC in ovarian cancer patients, identifying distinct cellular and molecular changes.

Aneuploidy-driven genome instability triggers resistance to chemotherapy

This study shows that aneuploidy-induced genome instability helps cancer cells resist chemotherapy by enabling survival under drug pressure.

Microbial colonization induces histone acetylation critical for inherited gut-germline-neural signaling

This study shows that microbial colonization induces histone acetylation in C. elegans germline, essential for transmitting bacterial aversion behavior across generations.

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

Signaling input from divergent pathways subverts malignant B-cell transformation

This study shows that malignant B-cell transformation requires convergence on a single oncogenic pathway, while divergent pathways can subvert transformation and are targets for new therapeutic strategies.

Quantifying E2F1 protein dynamics in single cells

This study quantifies E2F1 protein dynamics in single cells using fluorescent reporters, revealing cell cycle-dependent expression patterns and the impact of 3UTR sequences.

Resistance to decitabine and 5-azacytidine emerges from adaptive responses of the pyrimidine metabolism network

This paper identifies adaptive metabolic responses in pyrimidine metabolism as a mechanism of resistance to decitabine and 5-azacytidine, and shows that alternating these drugs with metabolic inhibitors can extend DNMT1 depletion and delay leukemia relapse.

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

This study identifies sex-specific roles of MDSC subsets in glioblastoma, showing mMDSCs drive growth in males and gMDSCs in females, with potential therapeutic targets.

Hispanic/Latino gastric adenocarcinoma patients have distinct molecular profiles including a high rate of germline CDH1 mutations

This study identifies distinct molecular profiles in Hispanic/Latino gastric cancer patients, including a high rate of CDH1 germline mutations linked to aggressive clinical outcomes.

Comparative transcriptome analysis of Powdery mildew Resistance between two Melon (Cucumis melo L) with Different Thickness Peel

This study compares the transcriptomes of two melon varieties with different peel thickness to identify genes associated with powdery mildew resistance.