Improving HEK293-based AAV-production using GSMMs, and a multi-omics approach
Leopold Zehetner, Diana Széliová, B. Kraus, Juan A. Hernández Bort, Jürgen Zanghellini
This study uses multi-omics analysis and GSMMs to identify metabolic bottlenecks in HEK293 cell AAV production, revealing HIF1alpha's role in pseudohypoxia and its impact on viral yield.
Metabolic Engineering · Apr 11, 2025Peer-reviewedBioengineering