F. Weiss

Identification of mCMQ069, a novel antimalarial with potential for a single-dose cure and/or 28-day chemoprevention

This paper identifies mCMQ069, a novel antimalarial with potential for single-dose cure and one-month chemoprevention, showing improved pharmacokinetic properties over KAF156.

Dendritic cell targeting in lymph nodes with engineered modular adapters improves HAdV5 and HC-HAdV5 tumor vaccination by co-secretion of IL-2v and IL-21

This paper develops a modular adapter system to target dendritic cells with adenoviral vectors, enhancing tumor vaccination by improving DC transduction and co-delivering cytokines.

Osteopontin in colitis-associated carcinoma

This study investigates the role of osteopontin (SPP1/OPN) in colitis-associated carcinoma (CAC) using a multi-omics approach, revealing its indirect immunosuppressive role in the tumor microenvironment.

Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Covalent Warhead

This paper introduces CMX990, a potent SARS-CoV-2 3CL protease inhibitor with improved potency and clearance compared to nirmatrelvir, advancing to Phase 1 clinical trials.

Cebranopadol, a novel long-acting opioid agonist with low abuse liability, to treat opioid use disorder: Preclinical evidence of efficacy

This study evaluates cebranopadol's efficacy and abuse liability in treating opioid use disorder using rat models, showing reduced self-administration and stress-induced reinstatement compared to heroin.

Sulfate limitation increases specific plasmid DNA yield and productivity in E. coli fed-batch processes

Multi-site assessment of reproducibility in high-content live cell imaging data

This study assesses reproducibility in high-content live cell imaging data across multiple sites and identifies sources of variability, showing that batch correction improves meta-analysis of perturbation experiments.

No atypical white-matter structures in grapheme- or color-sensitive areas in synesthetes

This study uses diffusion-weighted imaging to examine white matter structure in synesthetes and finds no differences compared to controls in color- and grapheme-processing areas.