Randomized gates eliminate bias in sort-seq assays
B. L. Trippe, B. Huang, E. A. DeBenedictis, B. Coventry, N. Bhattacharya, K. K. Yang, D. Baker, L. Crawford
The paper introduces randomized sorting in sort-seq assays to eliminate systematic bias, validated through simulation and experiments, and extends the method for variance estimation and multi-bin sorting.
bioRxiv · Feb 17, 2022Bioengineering