Biological and structural analysis of new potent Integrase-LEDGF allosteric HIV-1 inhibitors
E. Le Rouzic, D. Bonnard, F. Le Strat, C. Batisse, J. Batisse, C. Amadori, S. Chasset, S. Emiliani, B. Ledoussal, M. Ruff, F. Moreau, R. Benarous
This paper describes a new class of HIV-1 integrase-LEDGF allosteric inhibitors with potent anti-HIV activity, resistance to existing drugs, and a lead compound validated in a phase I trial.
bioRxiv · Jan 28, 2023 · PreprintMicrobiology