Uncoupled activation and cyclisation in catmint reductive terpenoid biosynthesis
B. Lichman, M. Kamileen, G. Tichman, G. Saalbach, C. Stevenson, D. Lawson, S. O'Connor
The paper identifies NEPS enzymes in catmint that catalyse stereoselective cyclisation of an enol intermediate into nepetalactol isomers, revealing uncoupled activation and cyclisation in reductive terpenoid biosynthesis.
bioRxiv · Aug 14, 2018Biochemistry