D. Zhao

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

This paper introduces DRAM, a method for transcriptome-wide m5C detection using deaminase and reader proteins, showing high overlap with BS-seq data and supporting low-input RNA.

BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health

This study shows that HSCs produce BMP9/10, which regulate KCs and ECs to maintain liver homeostasis, and their deletion leads to fibrosis and iron overload.

Unbiased functional genetic screens reveal essential RNA modifications in human cancer and drug resistance

The paper identifies essential RNA modifications in cancer using CRISPR screens and finds that mitochondrial metabolic plasticity influences drug resistance through specific RNA modifications.

Global Marine Cold Seep Metagenomes Reveal Diversity of Taxonomy, Metabolic Function, and Natural Products

The paper analyzes metagenomes from cold seeps to create a database showing microbial diversity and potential natural products.

A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration

Exogenous myristate fuels the growth of symbiotic arbuscular mycorrhizal fungi but disrupts their carbon-phosphorus exchange with host plants

This study shows that exogenous myristate supports AMF growth but reduces phosphorus transfer to host plants, suggesting it may hinder symbiosis.

ScRNA-seq and scATAC-seq reveal that sertoli cell mediate spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia

This study uses scRNA-seq and scATAC-seq to identify stage-specific interactions between Sertoli cell subtypes and germ cells in NOA, revealing potential molecular markers for diagnostic kits.

State-transition Modeling of Blood Transcriptome Predicts Disease Evolution and Treatment Response in Chronic Myeloid Leukemia

The paper uses transcriptome-based state-transition models to predict CML disease progression and treatment response using time-sequential blood samples from mice.

KRAS inhibition activates an actionable CD24 do-not-eat-me signal in pancreatic cancer

This study identifies CD24 as an actionable signal activated by KRASG12C inhibition in pancreatic cancer, enhancing macrophage phagocytosis and sensitizing tumors to therapy.

Adapting to heat stress by sowing summer grain crops early in late winter: Sorghum root growth, water use, and yield

This study shows that early sowing of sorghum in late winter or spring improves yield by reducing heat stress during flowering and enhancing water use efficiency.

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2

This study shows that oxytocin reduces colitis and CAC by enhancing MUC2 fucosylation via OXTR, suggesting it as a potential therapeutic for these conditions.

Anti-CD47 immunotherapy as a therapeutic strategy for the treatment of breast cancer brain metastasis

This study shows that blocking CD47 reduces brain metastasis in breast cancer by enhancing immune response and altering tumor microenvironment signaling.

Non-cell autonomous cardiomyocyte regulation complicates gene supplementation therapy for LMNA cardiomyopathy

This study shows that gene supplementation for LMNA cardiomyopathy is ineffective when targeting cardiomyocytes alone, as non-cell autonomous effects dominate, suggesting alternative therapeutic targets.

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

Tat-fimbriae ("tafi") - novel type of haloarchaeal surface structures

This study identifies and characterizes tat-fimbriae (tafi), novel haloarchaeal surface structures formed via the Tat-pathway, and demonstrates their synthesis in a heterologous host.

Bioavailability of Schisandrin B and its effect on 5-Fluorouracil metabolism in a xenograft mouse model of colorectal cancer

This study shows Schisandrin B enhances 5-Fluorouracil efficacy in colorectal cancer by modulating drug metabolism and reducing multidrug resistance.

Disruption of OsLAT5 is sufficient to endow rice tolerance to dihydropyridine herbicides at commercial application concentrations

This study shows that disrupting OsLAT5 in rice confers tolerance to dihydropyridine herbicides without affecting yield or grain quality.

Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches

This study investigates how zearalenone promotes colorectal cancer in mice through multi-omics analyses, revealing pathway activation, metabolic changes, and microbiota alterations.

Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma

The paper identifies 4 immunoprognostic genes in ccRCC using bioinformatics analysis of public databases and validates their association with prognosis and immunotherapy response.

CARD8 negatively regulates NLRP1 inflammasome activation level by interaction with NLRP1

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis

This study identifies the Hdc GC box as essential for Hdc gene transcription, histamine synthesis, and anaphylaxis in mice and human mast cells.

Enhancers that regulate TNF gene transcription in human macrophages in response to TLR3 stimulation

This study identifies enhancers regulating TNF gene transcription in human macrophages upon TLR3 stimulation and shows their functional importance.

Comparative genomic insights into the evolution of Halobacteria-associated "Candidatus Nanohaloarchaeota"

This paper identifies a new family of 'Ca. Nanohaloarchaeota' from hypersaline environments, showing they are an intermediate stage in the evolution of symbiosis with Halobacteria.

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

Quality Control Framework of TCM Preparations based on Multi-type Fingerprints using a Source Proportion Estimation Model

This paper proposes a quality control framework for TCM preparations using multi-type fingerprints and a source proportion estimation model to evaluate batch consistency and manufacturer differences.

IL-33 priming and antigenic stimulation synergistically promote the transcription of proinflammatory cytokine and chemokine genes in human skin mast cells

A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-Cov-2 virus and Omicron variant through a unique binding mode

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

Cas9-Mediated Knockout of Ndrg2 Enhances the Regenerative Potential of Dendritic Cells for Wound Healing

This study uses CRISPR/Cas9 to knockout Ndrg2 in dendritic cells, enhancing their regenerative capacity for wound healing in mouse models.

Omicron BA.2 specifically evades broad sarbecovirus neutralizing antibodies

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

Targeted Reactivation of X-linked Endogenous FOXP3 Gene from X-chromosome Inactivation in Human Female Breast Cancer Cells

This paper develops a CRISPRi/a approach to reactivate FOXP3 and silence XIST from XCI in human breast cancer cells, showing enhanced epigenetic changes and therapeutic potential.