Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolopyrimidines as Potential Candidates to Treat Human African Trypanosomiasis
L. Monti, L. J. Liu, C. Varricchio, B. Lucero, T. Alle, W. Yang, I. Bem-Shalom, M. Gilson, K. R. Brunden, A. Brancale, C. R. Caffrey, C. Ballatore
This study evaluates the structure-activity relationships, tolerability, and efficacy of microtubule-active triazolopyrimidines against Trypanosoma brucei, identifying two congeners with significant antiparasitic effects in vivo.
bioRxiv · Mar 11, 2023Microbiology