Author

A. Brancale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Zoology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Organism:human· 4 Approach:experimental assay· 3 Approach:statistical model· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Varricchio· 2 shared G. Padalino· 2 shared K. F. Hoffmann· 2 shared A. L. W. van Vliet· 1 shared B. Canard· 1 shared B. Coutard· 1 shared B. Hulme· 1 shared B. Lucero· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersMicrobiology

C. Varricchio

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolopyrimidines as Potential Candidates to Treat Human African Trypanosomiasis

L. Monti, L. J. Liu, C. Varricchio, B. Lucero, T. Alle, W. Yang, I. Bem-Shalom, M. Gilson, K. R. Brunden, A. Brancale, C. R. Caffrey, C. Ballatore

This study evaluates the structure-activity relationships, tolerability, and efficacy of microtubule-active triazolopyrimidines against Trypanosoma brucei, identifying two congeners with significant antiparasitic effects in vivo.

bioRxiv · Mar 11, 2023Microbiology

Geneticin shows selective antiviral activity against SARS-CoV-2 by interfering with programmed -1 ribosomal frameshifting

C. Varricchio, G. Mathez, T. Pillonel, C. Bertelli, L. Kaiser, C. Tapparel, A. Brancale, V. Cagno

This study shows geneticin inhibits SARS-CoV-2 by reducing -1 ribosomal frameshifting, effective against multiple variants in cell lines and tissue models.

bioRxiv · Mar 8, 2022Microbiology

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex

D. L. Hurdiss, P. El Kazzi, L. Bauer, N. Papageorgiou, F. P. Ferron, T. Donselaar, A. L. W. van Vliet, B. Canard, E. Decroly, A. Brancale, T. Zeev-Ben-Mordehai, F. Förster, F. J. M. van Kuppeveld, B. Coutard

This study identifies fluoxetine as an inhibitor of the enterovirus 2C AAA+ ATPase, revealing its mechanism of action through structural and functional analyses.

bioRxiv · Apr 26, 2021Microbiology

Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) is a druggable target involved in parasite survival, oviposition and stem cell proliferation.

G. Padalino, C. A. Celatka, H. Y. Rienhoff, J. H. Kalin, P. A. Cole, D. Lassalle, C. Grunau, I. W. Chalmers, A. Brancale, K. F. Hoffmann

This study investigates the anti-schistosomal activity of HsLSD1 inhibitors on S. mansoni life cycle stages and identifies compound 33 as effective against parasite survival, oviposition, and stem cell proliferation.

bioRxiv · Sep 17, 2020 · PreprintMicrobiology

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

K. Whatley, G. Padalino, H. Whiteland, K. Geyer, B. Hulme, I. Chalmers, J. Forde-Thomas, S. Ferla, A. Brancale, K. F. Hoffmann

This paper screens epigenetic probes/inhibitors against Schistosoma mansoni and identifies compounds targeting histone methylation/demethylation processes as potential anti-schistosomal agents.

bioRxiv · Aug 8, 2019Zoology