Tregs constrain CD8+ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy
J. R. Palmeri, B. M. Lax, J. M. Peters, L. R. Duhamel, J. A. Stinson, L. Santollani, E. A. Lutz, W. Pinney, B. D. Bryson, K. D. Wittrup
The paper shows that inhibiting Tregs enhances CD8+ T cell priming, improving antitumor responses to 4-1BB combination therapy.
bioRxiv · Jan 30, 2023 · PreprintImmunology