Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells
H. Donnelly, E. Ross, Y. Xiao, R. Hermantara, A. F. J. M. A. Taqi, W. S. Doherty-Boyd, J. Cassels, P. M. Tsimbouri, K. M. Dunn, J. Hay, Z. A. Cheng, N. Jain, C. C. West, H. Wheadon, A. M. Michie, , M. J. Dalby
This study develops a bioengineered niche that maintains long-term haematopoietic stem cells by recreating physiological extracellular matrix organisation, supporting their survival and function without media supplementation.
bioRxiv · Jul 28, 2022 · PreprintBioengineering