N. Jain

A mouse model of TB-associated lung fibrosis reveals persistent inflammatory macrophage populations during treatment

This study uses a mouse model of TB infection to investigate fibrosis mechanisms, finding persistent inflammatory macrophages and elevated matrix remodeling enzymes during treatment.

Clonal evolution of hematopoietic stem cells after cancer chemotherapy

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

Complete list of canonical post-transcriptional modifications in the Bacillus subtilis ribosome and their link to RbgA driven large subunit assembly

The paper identifies 25 rRNA modification sites in B. subtilis and links them to RbgA-dependent large subunit assembly.

Acute and sub-chronic toxicity of 6PPD-quinone to early-life stage lake trout (Salvelinus namaycush)

This study assesses the acute and sub-chronic toxicity of 6PPD-quinone to early-life stage lake trout, finding significant mortality and deformities at environmentally relevant concentrations.

Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.

Vps18 contributes to phagosome membrane integrity in Mycobacterium tuberculosis-infected macrophages.

This study identifies Vps18 as a host factor critical for maintaining phagosomal membrane integrity in Mtb-infected macrophages, showing increased phagosomal damage and reduced antibiotic efficacy in its absence.

Toxicokinetic Characterization of the Inter-Species Differences in 6PPD-Quinone Toxicity Across Seven Fish Species: Metabolite Identification and Semi-Quantification

This study identifies and semi-quantifies 6PPD-Quinone metabolites in fish species to explore inter-species differences in toxicity and detoxification.

Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states

This study identifies cell state variability as a key determinant of SARS-CoV-2 susceptibility by analyzing highly susceptible lung epithelial cells.

A quantitative fluorescence-based approach to study mitochondrial protein import

This paper introduces a fluorescence-based method for analyzing mitochondrial protein import with high sensitivity and quantification capabilities.

Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells

This study develops a bioengineered niche that maintains long-term haematopoietic stem cells by recreating physiological extracellular matrix organisation, supporting their survival and function without media supplementation.

Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response

This study shows that reducing Lamin-A/C levels enhances pro-inflammatory macrophage responses, and inhibiting its degradation or the IFN-β-STAT pathway can suppress inflammation.

Vaccine Protection Against the SARS-CoV-2 Omicron Variant in Macaques

This study evaluates vaccine efficacy against SARS-CoV-2 Omicron in macaques, finding that both humoral and cellular immune responses are necessary for virologic control.

Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response.

The paper identifies a late TLR2-dependent transcriptional response in macrophages to Mycobacterium tuberculosis mutants and shows how virulence factors interfere with this response to promote TB pathogenesis.

BH3 Profiling Identifies Selective BCL-2 Dependence of Adult Early T-cell Progenitor (ETP) Subtype of Acute Lymphoblastic Leukemia (ALL) Patients

This study identifies BCL-2 dependence in adult ETP-ALL and co-dependence on BCL-2 and BCL-XL in adult non-ETP-ALL, suggesting targeted therapies.

Cross-neutralization of SARS-CoV-2 by HIV-1 specific broadly neutralizing antibodies and polyclonal plasma

This study shows that HIV-1 broadly neutralizing antibodies and plasma from HIV-1 infected children can cross-neutralize SARS-CoV-2 by targeting conserved epitopes and glycans on the spike protein.

14-3-3 protein Bmh1 triggers short-range compaction of mitotic chromosomes by recruiting sirtuin deacetylase Hst2

This paper identifies Bmh1 as a mediator of Hst2 recruitment to phosphorylated H3 tails, facilitating mitotic chromosome compaction through deacetylase activity.

Single nucleus multi-omics regulatory atlas of the murine pituitary

The paper creates a single nucleus multi-omics atlas of the murine pituitary, revealing cell type-specific regulatory mechanisms and identifying a cis-regulatory region linked to fertility.

Scrutinizing the SARS-CoV-2 protein information for the designing an effective vaccine encompassing both the T-cell and B-cell epitopes

This paper designs a multi-epitope vaccine against SARS-CoV-2 by identifying conserved, antigenic epitopes that elicit both humoral and cellular immune responses.

Interaction of RSC chromatin remodelling complex with nucleosomes is modulated by H3 K14 acetylation and H2B SUMOylation in vivo

The paper uses in vivo photo-crosslinking to show how RSC chromatin remodeling complex interacts with nucleosomes through H3 K14 acetylation and H2B SUMOylation.

Global Modulation in DNA Epigenetics during Pro-Inflammatory Macrophage Activation

The paper investigates DNA methylation changes in macrophages during pro-inflammatory activation, showing rapid epigenetic modulation through oxidation and repair mechanisms.

Overcoming ibrutinib resistance by targeting phosphatidylinositol-3-kinase signaling in diffuse large B-cell lymphoma

This study identifies phosphatidylinositol-3-kinase-beta upregulation as a mechanism of ibrutinib resistance in diffuse large B-cell lymphoma and shows that targeting this pathway with KA2237 can overcome resistance.

Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphoma

This paper shows that HDAC3 inhibitors reverse CREBBP mutation-driven epigenetic changes in lymphoma, inhibiting tumor growth and restoring immune surveillance.

Mesenchymal stem cells (MSCs) offer a drug tolerant and immune-privileged niche to Mycobacterium tuberculosis

This study shows mesenchymal stem cells (MSCs) provide a drug-tolerant and immune-privileged niche for Mycobacterium tuberculosis, with implications for tuberculosis treatment.