Author

J. Hay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell-cell communication· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

A. M. Michie· 4 shared K. M. Dunn· 3 shared O. J. Sansom· 3 shared C. Nixon· 2 shared J. Cassels· 2 shared J. Edwards· 2 shared K. Pennel· 2 shared N. Malik· 2 shared

Activity by Year

2022-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCancer Biology

A. M. Michie

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers

J. A. Waldron, G. Kanellos, R. C. L. Smith, J. R. P. Knight, J. Munro, C. Alexandrou, N. Vlahov, L. Pardo-Fernandez, M. Moore, S. L. Gillen, D. Strathdee, D. Stevenson, F. C. Warrander, K. Gilroy, C. Nixon, , O. J. Sansom

This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.

bioRxiv · Nov 10, 2023 · PreprintCancer Biology

IL-27 maintains cytotoxic Ly6C+ gamma delta T cells that arise from immature precursors

R. Wiesheu, S. C. Edwards, A. Hedley, M. Tosolini, M. G. F. Fares da Silva, N. Sumaria, Y. Optaczy, D. G. Hill, A. J. Hayes, J. Hay, A. Kilbey, A. M. Michie, G. Graham, A. Manoharan, C. Halsey, , S. B. Coffelt

The paper identifies immature and mature subsets of IFNγ-producing γδ T cells, showing IL-27 supports cytotoxic function in mature cells but not immature ones.

bioRxiv · Oct 26, 2023Immunology

Spatially Resolved Transcriptomics Deconvolutes Histological Prognostic Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

C. S. Wood, K. Pennel, H. Leslie, A. Legrini, A. Cameron, L. Melissourgou-Syka, J. Quinn, H. Van Wyk, J. Hay, A. Roseweir, C. Nixon, C. Roxburgh, D. McMillan, A. Biankin, O. J. Sansom, , N. Jamieson

This study uses spatial transcriptomics to identify prognostic immune and stromal subgroups in colorectal cancer liver metastases, revealing distinct transcriptomic programs associated with survival outcomes.

bioRxiv · Sep 21, 2022 · PreprintCancer Biology

PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signaling

J. Hay, A. Tarafdar, A. Holroyd, H. A. Moka, K. M. Dunn, A. Alshayeb, B. H. Lloyd, J. Cassels, N. Malik, A. F. Khan, I. Sou, J. Lees, H. N. Almuhanna, N. Kalakonda, J. R. Slupsky, A. M. Michie

This study shows PKCβ promotes CLL by enhancing BCR signaling and identifies SP1 as a regulator of PKCβ expression in leukemogenesis.

bioRxiv · Sep 4, 2022 · PreprintCancer Biology

Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells

H. Donnelly, E. Ross, Y. Xiao, R. Hermantara, A. F. J. M. A. Taqi, W. S. Doherty-Boyd, J. Cassels, P. M. Tsimbouri, K. M. Dunn, J. Hay, Z. A. Cheng, N. Jain, C. C. West, H. Wheadon, A. M. Michie, , M. J. Dalby

This study develops a bioengineered niche that maintains long-term haematopoietic stem cells by recreating physiological extracellular matrix organisation, supporting their survival and function without media supplementation.

bioRxiv · Jul 28, 2022 · PreprintBioengineering

mTORC1 activity is essential for disease progression in chronic lymphocytic leukemia

N. Malik, J. Hay, K. M. Dunn, R. Nakagawa, O. J. Sansom, A. M. Michie

This study shows that mTORC1 is essential for CLL progression in mice, with rapamycin effectively targeting eEF2 to inhibit proliferation and MCL1 expression.

bioRxiv · Apr 19, 2022 · PreprintCancer Biology