Rationally designed Gla-domainless FXa as TFPI bait in hemophilia
A. Thomas, M.-C. Dagher, A. Ersayin, L. Seyve, M. Castellan, C. Moreau, L. Choisnard, N. Thielens, R. Marlu, B. Polack
The paper designs and tests GD-FXa variants to enhance TFPI binding and coagulation restoration in hemophilia.
bioRxiv · Aug 3, 2022 · PreprintBioengineering