The Endothelium Modulates the Prothrombotic Phenotype of Factor V Leiden: Evidence from an Ex Vivo Model
N. Schwarz, J. Muller, H. L. McRae, S. Reda, B. Pezeshkpoor, J. Oldenburg, B. Potzsch, H. Ruhl
This study shows that endothelial cells from asymptomatic Factor V Leiden carriers have a higher APC response to thrombin formation compared to those with previous VTE, suggesting endothelial modulation of FVL's prothrombotic phenotype.
bioRxiv · Nov 15, 2023Pathology