Aberrant activation of Wnt/β-Catenin signaling pathway drives the expression of poorprognosis-associated microRNAs in adrenocortical cancer with a major impacton miR-139-5p and its host gene PDE2A
J. CRISTANTE, S. REDA EL SAYED, J. DENIS, B. RAGAZZON, C. HANTEL, O. CHABRE, L. GUYON, N. CHERRADI
This study shows that Wnt/β-Catenin signaling activation in adrenocortical cancer upregulates poor-prognosis miRNAs, particularly miR-139-5p, which is linked to PDE2A repression and NDRG4 activation.
bioRxiv · Feb 10, 2023 · PreprintCancer Biology