Binding and activation of serotonergic G-protein coupled receptors by the multimodal antidepressant vortioxetine.
L. K. Ladefoged, R. Koch, P. C. Biggin, B. Schioett
This study uses in silico analysis to examine vortioxetine's binding and activation mechanisms at 5-HT1A, 5-HT1B, and 5-HT7 receptors, revealing insights into agonist-antagonist behavior and activation without hydrogen bonding to helix 5.
bioRxiv · Jan 5, 2021Biophysics