Design of efficient artificial enzymes using crystallographically-enhanced conformational sampling
R. V. Rakotoharisoa, B. Seifinoferest, N. Zarifi, J. D. M. Miller, J. M. Rodriguez, M. C. Thompson, R. A. Chica
This paper designs artificial enzymes with high catalytic efficiency using crystallography-enhanced computational methods, achieving improvements comparable to directed evolution.
bioRxiv · Nov 1, 2023Biochemistry