Author

N. Zarifi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein design· 2 Assay:protein structure· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

M. C. Thompson· 2 shared R. A. Chica· 2 shared R. V. Rakotoharisoa· 2 shared A. Broom· 1 shared B. Seifinoferest· 1 shared E. Nguyen· 1 shared J. D. M. Miller· 1 shared J. M. Rodriguez· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

M. C. Thompson

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2 papers

Recent·Most cited

Design of efficient artificial enzymes using crystallographically-enhanced conformational sampling

R. V. Rakotoharisoa, B. Seifinoferest, N. Zarifi, J. D. M. Miller, J. M. Rodriguez, M. C. Thompson, R. A. Chica

This paper designs artificial enzymes with high catalytic efficiency using crystallography-enhanced computational methods, achieving improvements comparable to directed evolution.

bioRxiv · Nov 1, 2023Biochemistry

Evolution of an enzyme conformational ensemble guides design of an efficient biocatalyst

A. Broom, R. V. Rakotoharisoa, M. C. Thompson, N. Zarifi, E. Nguyen, N. Mukhametzhanov, L. Liu, J. S. Fraser, R. A. Chica

The paper uses X-ray crystallography to study conformational changes in an evolved enzyme, leading to the design of a more efficient biocatalyst by focusing on active-site mutations.

bioRxiv · Mar 19, 2020Biophysics