Rapid BCMA downmodulation on myeloma cells upon CAR T cell contact is mediated by trogocytosis and BCMA internalization
N. Camviel, B. Wolf, G. Croce, D. Gfeller, V. Zoete, C. Arber
This study designs APRIL-based dual-antigen CAR T cells for multiple myeloma and finds rapid BCMA downmodulation on tumor cells through trogocytosis and internalization, independent of binding moiety.
bioRxiv · Jul 23, 2022 · PreprintImmunology