Interpretable adenylation domain specificity prediction using protein language models
Abhinav Adduri, Andrew T. McNutt, Caleb N. Ellington, Krish Suraparaju, Nan Fang, Donghui Yan, Benjamin Krummenacher, Sitong Li, Camilla Bodden, Eric P. Xing, Bahar Behsaz, David Ryan Koes, Hosein Mohimani
The paper introduces MASPR, a machine learning method using protein language models to predict adenylation domain substrate specificities, enabling the prediction of hybrid NRP-PK natural products.
bioRxiv · Jan 13, 2025 · PreprintBioinformatics