T cell engagers convert acute tumor killing into endogenous vaccination
Mathilde M. Lecuit, Béatrice Corre, Zacarias Garcia, Fabrice Lemaı̂tre, Amaury Vaysse, Ruby Alonso, Christel Goudot, Baptiste Arnaud, L Feldmann, Carolina Moraes Cabe, Valérie Seffer, Pierre Guermonprez, Capucine L. Grandjean, Marion V. Guérin, Philippe Bousso
This study shows that T cell engagers induce endogenous vaccination by triggering a cytotoxic wave and cross-priming of CD8 T cells via dendritic cells.
bioRxiv · Oct 12, 2026 · PreprintImmunology