The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration
Duncan J. Hart, Md. Jashim Uddin, Rebecca J. Dodd, Savannah G. Brovero, Claire Fleming, G. Brett Moreau, Nick R. Natale, Farha Naz, Barbara J. Mann, Tara E. Sutherland, Judith E. Allen, Anthony J. Day, William A. Petri
This study shows that blocking CD44, a hyaluronan receptor, reduces inflammation and improves survival in mice infected with SARS-CoV-2.
PLoS Pathogens · May 20, 2026Peer-reviewedImmunology