Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
Elizaveta Bashkirova, Nell Klimpert, Kevin Monahan, Christine E. Campbell, Jason M. Osinski, Longzhi Tan, Ira Schieren, Ariel Pourmorady, Beka Stecky, Gilad Barnea, Xiaoliang Sunney Xie, Ishmail Abdus-Saboor, Benjamin Shykind, Bianca Jones Marlin, Richard M. Gronostajski, , Stavros Lomvardas
The paper shows that opposing epigenetic forces in olfactory progenitors spatially restrict stochastic OR choice through transcription and silencing influenced by NFIA, B, and X gradients.
eLife · May 12, 2023Peer-reviewedGenomics