TMEM165 replenishes lysosomal calcium stores, protects cells against calcium overload, and mediates calcium-induced lysosomal H+ leakage
Ran Chen, Bin Liu, Dawid Jaślan, Lucija Kucej, Veronika Kudrina, Belinda Warnke, Yvonne Eileen Klingl, Arnas Petrauskas, Sandra Prat Castro, Kenji Maeda, Christian M. Grimm, Marja Jäättelä
This study identifies TMEM165 as a lysosomal calcium importer that prevents calcium overload and regulates lysosomal pH.
Nature Communications · Jun 5, 2025Peer-reviewedCell Biology