The multidrug transporter Pdr5 from Saccharomyces cerevisiae is an ergosterol-modulated efflux pump
Lea‐Marie Nentwig, Jakob Helmbrecht, Elise Kaplan, Sakshi Khosa, Haigang Song, Philipp Westhoff, Carol V. Robinson, Sander H. J. Smits, Andrzej Harris, Marten Exterkate, Ben Luisi, Lutz Schmitt
This study reports the cryo-EM structure of Pdr5, showing ergosterol binding and its effect on transporter activity, with implications for fungal drug resistance.
bioRxiv · Oct 30, 2026 · PreprintBiochemistry